Skip to main content

Professor Amos Burke appointed Director of Birmingham’s Cancer Research UK Clinical Trials Unit (CRCTU)

Professor Amos Burke has been appointed as the new Director of the Cancer Research UK Clinical Trials Unit, based at BHP founder-member the University of Birmingham.

Professor Burke – a paediatric oncologist and has held a consultant position in the NHS since 2004 – joins the Unit from Cambridge University Hospitals NHS Foundation Trust.  With a particular interest in childhood lymphomas, Professor Burke chaired the UK paediatric Non-Hodgkin Lymphoma subgroup of the National Cancer Research Institute (NCRI) Lymphoma Clinical Studies Group (2010-2018), remaining an active member (2019-2023). Since 2023 he has been the Deputy Chair of the UK Children’s Research Group (currently supported by the Children’s Cancer and Leukaemia Group).

Commenting on his appointment, Amos said: “I am delighted to be joining CRCTU as it approaches its 40th year of CRUK funding as a result of its work under the leadership of the former Directors, most recently Professor Pam Kearns who brought children’s cancer trials into the unit during her tenure. CRCTU is nationally and internationally known for its trials in childhood and adult cancer, addressing unmet clinical needs and leading the use of innovative trial design. I look forward to leading CRCTU going forward as new approaches to increasingly complex trials involving more global collaboration are required.”

As the new Director of the CRCTU, he is responsible for the delivery of clinical cancer trials for children and young people in England. The CRCTU collaborates with clinician investigators driving cutting-edge research, with a focus on treatments that will change outcomes for people with cancer.

Professor Burke is currently the Chief Investigator for the innovative platform trial Glo-BNHL for children with relapsed and refractory mature B-cell Non-Hodgkin Lymphoma.

High-profile appointee heightens ambition for Birmingham Health Partners

The second city’s strategic University-NHS alliance, Birmingham Health Partners (BHP) has announced the appointment of experienced business leader Jonathan Pearson as its new Chair, tasked with implementing an ambitious new strategy.

Bringing extensive experience as a management consultant and a profound understanding of the health and life sciences sector, Jonathan has established and guided numerous healthcare enterprises, spearheaded significant growth, and led large-scale transformation and technology programmes. He has also served within the NHS as Independent Chair of the Sandwell and West Birmingham Health System, bringing together a unique blend of high-level industry and health service expertise.

Jonathan’s contributions to the sector have earned him several prestigious accolades throughout his career. Notably, he was honoured with the Healthcare Deal of the Year award in 2014 by Acquisition International, recognised by the Management Consultancy Association in 2015 for thought leadership, and received the HSJ award for Analytic Provider of the Year in 2019. His exceptional leadership in the Sandwell ICP’s Covid vaccination program was further acknowledged with the Local Government Association award in 2021.

BHP is a strategic alliance uniting two renowned Universities, five NHS Trusts and Health Innovation West Midlands, with the shared aim of transforming healthcare across our region by leveraging collective strengths in clinical and technological innovation, research, and education.

Commenting on his appointment, Jonathan said: “Birmingham Health Partners is a powerhouse of research at the heart of an ambitious city and region, with a strong track record of scaling innovation from the bench to the bedside at pace. Together with its wider regional partners, BHP is already working to address pressing health challenges and deliver economic growth and this work will only be enhanced by the imminent launch of our new strategy which will benefit our communities, region and workforce. It is an incredibly exciting time to join the partnership.”

Spinal injury model funding awarded to BHP members

BHP members the Royal Orthopaedic Hospital and Aston University – working with the University of Edinburgh – have been awarded a joint research fellowship to develop a working 3D model of the spinal cord, to improve understanding of the management of compressive spinal cord pathology.

The fellowship is funded by Orthopaedic Research UK (ORUK), the British Association of Spine Surgeons (BASS) and the British Scoliosis Society (BSS) and the project will run for three years. The team is led by Professor Adrian Gardner – consultant spine surgeon at the Royal Orthopaedic Hospital and Jean-Baptiste Souppez – senior lecturer mechanical, biomedical and design engineering at Aston University. 

The idea for the project came about following a discussion between colleagues about a patient presenting with a multi-level degenerative cervical spine with multi-level spondylolisthesis. Multiple vertebra in the patient’s neck were compressing on each other and several of these vertebra were pushed forwards creating an unstable spine. 

Professor Gardner said: “I was able to make recommendations, however this was based on training over the years and experience. For example, there are multiple ways to approach this kind of injury – you could go in from the front (anterior) or the back (posterior), but the decision is largely down to how you’ve been trained.  It occurred to me that a physical model could be used to better understand the pathology and use scientific evidence to inform surgical solutions for our patients here at the Royal Orthopaedic Hospital and across the globe.”

Professor Gardner worked through potential options with contacts at Aston University, who recommended using 3D printing to simulate the different ways spinal cord compression happens, and its management. The model would be made up of a 3D printed, fully articulated vertebral column and use tuneable pneumatic pressure to replicate the spinal cord. Adjustable to reflect various spinal conditions, the model would enable spinal teams to test the likely impact of different procedures.

Degenerative Cervical Myelopathy (DCM) is one of the most common spinal injuries, caused by severe compression in the neck. This compression can come because of inflammation, arthritis and age. It can lead to issues with balance, dexterity and control of the bowel and bladder. If left untreated, myelopathy can lead to permanent spinal cord injury and nerve damage. 

Professor Gardner added: “Despite being common, DCMs are under researched. As spinal surgeons we often refer to it as a silent disease – studies show about 2% of the adult population have DCM, but the real number could be much higher. This is because patients may not be aware that they have a degenerative cervical myelopathy and will put their symptoms down to aging, never seeking out treatment. 

“With this fellowship we have the chance to enhance understanding of the best way to treat this under-researched condition and better support clinicians with their management plans. Timing is key in treating people with DCM to maximise recovery and outcomes, but surgeons have always been appropriately cautious due to the lack of research in this space. Ultimately, we hope that this model will help demonstrate that earlier intervention can prevent DCM becoming a serious disability.”

The project is supported by three students from the University of Aston who sit across different engineering disciplines: Design Engineering, Biomedical Engineering and Mechanical Engineering. 

Jean-Baptiste R. G. Souppez, senior lecturer in mechanical, biomedical and design engineering at Aston, co-lead on the project, commented: “The award of the inaugural ORUK/BASS/BSS fellowship has been instrumental in enabling this joint research project between the Royal Orthopaedic Hospital and Aston University’s Mechanical, Biomedical and Design Engineering department. 

“It is also fantastic to see the joint effort from three engineering disciplines, coming together to strengthen our commitment to our local community partners, developing innovative solutions to real-world problems as part of our Engineering for Health research centre at Aston University.” 

Our shared future – BHP publishes annual review of activity

Following a year in which Birmingham Health Partners expanded its membership to eight member organisations – welcoming Aston University and Birmingham and Solihull Mental Health NHS Foundation Trust – we’re pleased to publish our second annual review of activity for the period September 2022-August 2023. 

Download and read the Birmingham Health Partners Report of Activity 22-23  (PDF, 5MB)

Over the past year, BHP has demonstrated the benefits of collaboration across our organisations. The addition of new members and the emergence of integrated care systems together with changes in the funder landscape offer new opportunities for BHP to continue to develop and promote our collaborative purpose.

The year ahead will see us welcome a new Chair, new leaders at some of our Partner organisations and the publication of a strategic framework and delivery plan that reflects our ambitions for the region.

We have in our hands the tools that we need to succeed, the onus is on us to put them to work to ensure Birmingham is seen as the place where innovative research translates into improved health and economic growth.

Outgoing chair Ed Smith commented: “We were delighted to welcome Aston University and Birmingham and Solihull Mental Health NHS Foundation Trust to our membership during the year and now comprise two universities, five NHS Trusts, and the West Midlands AHSN. Our collaboration between such significant partners allows us to focus on research, innovation and health care capabilities to deal with important health issues in the region and indeed beyond through wider partnerships. 

“BHP’s key activities over the last year have been a focus on women’s health; improving the environment for clinical research fellowships; and our forward strategy for the next five years – which has been approved by the BHP Board and is focussed on delivering real value to the region from collaborative and skilled contributions which, in the prioritised areas, would be less effective than those from single organisations working individually.”

Downloads:

Birmingham Health Partners Report of Activity 22-23  (PDF, 5MB)
Birmingham Health Partners Report of Activity 2020 to 2022 pdf (4MB)

BHP members collaborate to explore tech, big data and AI in healthcare

Two members of Birmingham Health Partners – Aston University and Birmingham Women’s and Children’s NHS Foundation Trust (BWC) – are collaborating to explore how digital technology, big data and artificial intelligence can revolutionise healthcare.

To kick off the partnership, Aston University’s Engineering for Health Research Centre is co-hosting the BWC Innovation Summit, which brings together tech firms, healthcare professionals and academics to explore how new technology can benefit paediatric and women’s healthcare as well as the young people’s mental health sector.

Representatives from Hitachi, KPMG and the West Midlands Academic Health Science Network (WMAHSN) will be at the event on October 11th held at Conference Aston.

Amanda Baugh, Head of Innovation at BWC said: “The event is an opportunity to bring together professionals from different disciplines to foster collaboration and springboard ideas on the future of healthcare.

“We want to get a wide range of experts in one place to explore and define challenges and set out plans about how we can adapt and adopt existing technology, products and devices, along with how we might develop products and solutions not currently available to meet these challenges.”

Dr Antonio Fratini is head of Aston University’s Engineering for Health Research Centre. He said: “The University’s College of Engineering and Physical Sciences is delighted to be co-hosting this event which highlights Aston University’s mission to be a leading university of science, technology and enterprise.

“Through harnessing the power of medical and digital technology, analysis of big data and artificial intelligence we will be able to change healthcare – for example by providing care closer to home, improving access and therefore reducing inequalities.”

NIHR awards £4m to Birmingham Clinical Research Facility to enhance the delivery of research

The Birmingham NIHR Clinical Research Facility (CRF) has been awarded £4 million from the National Institute for Health and Care Research (NIHR).

This funding is part of a total investment of £96 million that has been awarded to NHS organisations across England, to enhance the delivery of research through improving research facilities for patients across the NHS, helping teams to find new ways to prevent and treat diseases.

The Birmingham NIHR CRF is a collaboration between three BHP members – University Hospitals Birmingham NHS Foundation Trust (UHB), Birmingham Women’s and Children’s NHS Foundation Trust (BWC) and the University of Birmingham (UoB).

In Birmingham, new equipment will enable the delivery of innovative health technology services, including a range of cell and gene therapies requiring specialist pharmacy facilities. For example, onsite isolators will support preparation within the research facilities, speeding up the delivery of CAR-T trials for patients with haematology (blood) cancers, as well as trials into cancer vaccines for patients with a variety of solid tumour cancers.

The funding will also provide new laboratory equipment, essential for storing samples from patients recruited to metabolic research studies. This will support researchers with ground breaking work in the prevention, treatment and management of metabolic disease for adults and children across Birmingham.

The bid was led by Jo Gray, NIHR Birmingham Clinical Research Facility Clinical Manager, who said: “This successful bid for equipment and upgrades to our facility is fantastic and will make such a difference to patients and research teams across all partner sites.

“We have ambitious plans in place to upgrade existing equipment, as well as increase our ability to support new research across the sites. New equipment will include a paediatric ‘peapod’, which measures body composition and growth in premature born infants, and biosafety cabinets, which provide an enclosed ventilated space for drug preparation.

“Our portfolio of gastrointestinal (GI) and respiratory studies will also be able to grow with the addition of new endoscopy equipment. One of the key GI trials to benefit will be the INCEPTION clinic for patients with Inflammatory Bowel Disease (IBD). This trial aims to improve diagnosis and prognosis, and make more informed decisions on IBD treatment through biomarker discovery and implementation, by understanding more about how different microbiomes affect gut and oral immune responses.”

Professor Lorraine Harper, NIHR Birmingham Clinical Research Facility Programme Director, added: “We are tremendously proud that our hospitals have been selected for this award from the NIHR to improve the delivery of research in our local population. The award, which builds on existing clinical-academic collaborations facilitated by Birmingham Health Partners, will benefit our adult and paediatric patients, improving their access to new therapies and treatments, which can potentially be life-changing.”

Dr. Jan Idkowiak, NIHR Birmingham Clinical Research Facility Director (BWC), said: “This is very exciting. This award allows us to expand our ability to deliver cutting-edge clinical research beyond the Children’s Hospital, as it will enable us to include pregnant women and their children at the Women’s Hospital. This will be a huge benefit for our patients and will offer great opportunities to develop new therapies.”  

Professor Philip Newsome, Director of the NIHR Birmingham Biomedical Research Centre (BRC), commented: “This is fantastic news for both the CRF and for the organisations that work with them, like the Birmingham BRC. The CRF has been a key partner in delivering many of our experimental research studies, and we collaborate closely on our training, patient and public involvement, and equality, diversity and inclusion programmes too. We are looking forward to continuing working together to deliver patient benefit.”